Bo's Tests Prove Long Term Peanut Allergy Cure from OIT

Just wanted to share some exciting test result news about Bo's continued long term success with tolerance to peanuts years after he completed his peanut allergy oral immunotherapy treatment at Arkansas Childrens Hospital.

Quick Summary of Bo's 14 Year Peanut Allergy Cure Journey:

  1. In November 2006, Bo was diagnosed with peanut allergy at 5 years old after having a severe allergic reaction after eating a portion of a candy bar that contained peanut.
  2. In July 2007, he began a blinded study OIT protocol with peanut IgE blood score >100 kU/L at Arkansas Childrens Hospital under the care of Dr. Stacie Jones.  Unbeknown to us at the time, he was receiving placebo therapy for the first year of treatment. So no surprise that at end of year one, his tests showed he was still allergic to peanuts. Quite the bummer but it proved valuable data as the placebo had no effect.
  3. July 2008 (after receiving placebo for year 1), Bo was switched to real peanut flour OIT eaten daily with applesauce or pudding. His peanut flour doses were then escalated every 2 weeks until he reached his top daily maintenance dose of 4,000 mg (equal to about 13 peanuts). We drove from south Louisiana to Little Rock weekly or twice a month for years for Bo's treatment.
  4. In 2012 Bo reached his treatment endpoint which required repeat oral food challenge up to 5,000 mg peanut protein (~16.5 peanuts). He passed the food challenge while on therapy without any symptoms, confirming his status of “desensitized.” His peanut IgE blood score was down to 9.3 kU/L.
  5. His daily peanut dosing was then discontinued for 6 weeks, and another food challenge was conducted to further assess any potential for allergic reaction to peanut while off therapy. He passed a 5,000 mg peanut protein (~16.5 peanuts) food challenge that was consumed without symptoms then was able to consume 10,000 mg of peanut protein (~33 peanuts) without symptoms noted, resulting in his status being redefined as “sustained unresponsiveness.” He was advised to add peanut to his diet 2-3 days per week to maintain his clinical status.
  6. For the last 2 years Bo rarely ate his suggested weekly peanut maintenance dose.
  7. In December 2019, Bo was accepted into Vanderbilt for Fall of 2020 and was awarded a 4 year Army ROTC scholarship!
  8. In March 2020, Bo was notified by the Army that he would be required to provide additional documentation and testing to verify that he is no longer allergic to peanuts.
  9. May 2020 test results: Bo's IgE blood score is now all the way down to 1.09 kU/L and he passed his food challenge by consuming 7.5 grams of peanut butter with no allergic reaction what so ever! (Though he still does not like the smell or texture of peanut butter!)

So 8 years after completing oral immunotherapy treatment for peanut allergy and years after stopping weekly peanut maintenance dosing, Bo has test results that officially prove he is no longer allergic to peanuts!

We greatly appreciate all the people who treated and supported Bo along his years long journey to being cured of his peanut allergy!




Bo Talbot & Family

Bo Still Doing Great 8 Yrs After Completing Peanut Allergy Oral Immunotherapy!

By request we have re-activated Bo's blog to update everyone about his progress since completing his peanut oral immunotherapy at age 10. It's April 2020 and Bo is now 18, preparing to graduate high school and enroll in college and Army ROTC. He is still living a normal, active life with no dietary or activity restrictions at all. We have NOT been making any special accommodations for peanuts for over 8 years now! We are so proud that Bo's participation in his pioneering OIT study has led to the widespread availability of these lifesaving food allergy desensitization treatments around the world and the recent FDA approved drug treatment for peanut allergy!

Bo_Vandy_ROTC Visit_Small

Peanut Allergy Treatments Continue to Advance

Amazing how far peanut allergy oral immunotherapy and other severe food allergy treatments have come in the 13 years since Bo was first diagnosed with a severe peanut allergy and was enrolled in a groundbreaking treatment and study program at Arkansas Children's hospital as patient #2!

Bo has lived a normal life since completing his oral immunotherapy program at age 10 by successfully passing a food challenge. In fact, in the last year of the 5 year study he was eating 34 peanut butter M&Ms everyday to build and maintain his desensitization to peanuts.

Sounds cool to eat candy to cure a deadly peanut allergy but not an easy thing to do to eat that much every day for such a long period of time. But in the end all the time and effort were worth his life changing success!


FDA Approves First Drug for Treatment of Peanut Allergy for Children

Today the U.S. Food and Drug Administration approved Palforzia [Peanut (Arachis hypogaea) Allergen Powder-dnfp] to mitigate allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanuts. Treatment with Palforzia may be initiated in individuals ages 4 through 17 years with a confirmed diagnosis of peanut allergy and may be continued in individuals 4 years of age and older. Those who take Palforzia must continue to avoid peanuts in their diets.

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Bo Still Cured 4 Years After Peanut Allergy Treatments Ended

It has been nearly four years since Bo ended his peanut allergy oral immunotherapy at Arkansas Children’s Hospital in Little Rock. So we wanted to provide a quick update on the continuing success of his peanut desensitization.

Today, Bo is a healthy, happy eighth grader that is as "normal" as a 14 year old teenager in high school can be, especially considering for many years he suffered with a life threatening peanut allergy.

The only remaining aspects of his five years of peanut allergy oral immunotherapy treatments is that he eats a Snicker’s ice cream bar every 3-5 days to maintain his desensitization to peanuts.

We do not worry about what foods he eats (other than encouraging him to eat healthy and in moderation) as any person should. When we are asked by Doctors or restaurants if he has any food allergies… our answer is …“No”.

So as one of the pioneers in the earliest food allergy treatment programs, Bo is living proof that oral immunotherapy treatment programs can be successful at generating long-term cures for deadly food allergies, like peanuts. Thanks Dr. Stacie Jones, nurse Karen and team at Arkansas Children’s Hospital!

Prayers for everyone who suffers with life threatening food allergies, as well as, their families, friends and the health workers who are dedicated to ending them.

Now if only we could get him to routinely put his dirty clothes in the hamper instead of scattered across his bedroom floor. Anyone know of any cures for that teenage syndrome?

May God bless you all!


Bo and family